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General Discussion / Multicollinearity
« on: September 07, 2018, 07:13:59 am »
Hello,
I would like to use the Transfactivity tool from the REDUCE suite. One concern that I have is that if you use a large set of matrices (PWMs), some will be very similar and so can induce multicollinearity in their scores at promoter regions, and it will introduce multicollinearity between them in the multiple linear regression analysis. If so, then the activities of each TF associated to the similar PWMs might be wrong. Any insight/advice on how to tackle that? It does not seem that you take that into consideration in the previous usage of the tool.
Thanks
Best
AM
I would like to use the Transfactivity tool from the REDUCE suite. One concern that I have is that if you use a large set of matrices (PWMs), some will be very similar and so can induce multicollinearity in their scores at promoter regions, and it will introduce multicollinearity between them in the multiple linear regression analysis. If so, then the activities of each TF associated to the similar PWMs might be wrong. Any insight/advice on how to tackle that? It does not seem that you take that into consideration in the previous usage of the tool.
Thanks
Best
AM